Important News About Epinephrine Auto-InjectorsFeatured Content

This content has been updated for 2014 and can be found here: http://community.kidswithfooda...e-united-states-2014


Commercially Available Epinephrine Auto-Injectors Available with a Prescription in the United States


by Angela Nace, PharmD

Epinephrine auto-injectors remain the mainstay treatment for anaphylaxis. Several epinephrine auto-injectors are now available in the United States (including a generic version). Each contains the drug epinephrine, but each device has its own unique set of instructions for use. Understanding the differences is important to ensure that you get the device you want and you know how to properly use it.

epi-differences-pdfThis downloadable chart summarizes the key facts and patient information pertaining to each of the currently available epinephrine auto-injectors. All listed auto-injectors are available in twin packs which contain two (2) pre-filled devices. Additional details, including patient instructional videos, are available at the manufacturers’ websites.

Please be mindful of state and federal dispensing regulations that pharmacists must follow when filling your prescription for epinephrine.

It is important to note that there are many states in which the pharmacist is allowed to substitute a generic form of the prescription when indicated on the prescription and after receiving a verbal approval from the physician. If you or your physician prefer to receive a specific brand name of epinephrine auto-injector, your physician must indicate the brand name and “DAW” (dispense as written) or “do not substitute” on the prescription. This indication prohibits the pharmacist from dispensing a generic form of the prescription. Regardless, before you leave the pharmacy, make sure the pharmacy fills your prescription exactly as you and your child's doctor expects.

Remember to speak to your child’s physician to determine which epinephrine product is best for your child. Since each device operates differently, make sure that you have been adequately trained to use the device that you leave the pharmacy with and review the training video for that device.





Epinephrine Injection, USP auto-injector, authorized generic (AG) of Adrenaclick™

EpiPen™ and EpiPen Jr™




  1. Product information for Adrenaclick™. Amedra Pharmaceuticals LLC. Horsham, PA 19044. June 2012.
  2. Product information for Auvi-Q™. Sanofi-Aventis U.S. Bridgewater, NJ 08807. September 2012.
  3. Product information for Epinephrine Injection, USP auto-injector, the authorized generic (AG) of Adrenaclick™. Lineage Therapeutics. Horsham, PA 19044. March 2013.
  4. Product information for EpiPen. Mylan Inc. Basking Ridge, NJ 07920. August 2012.

angela-naceAngela Nace is Field Coordinator for Experiential Education, Department of Pharmacy Practice, at Jefferson University School of Pharmacy. She is also a member of the Kids With Food Allergies (KFA) Board of Directors and Liaison to the KFA Medical Advisory Team.

Last edited by melkorey July 9, 2014 2:39 PM
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EpiPen and EpiPen Jr Epinephrine Auto-Injector
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