Welcome to our August research update! Getting involved with research is an important way to impact food allergy treatments, education, and awareness.

This month, we are highlighting clinical trials, interviews, focus groups, and news on:

• Under-the-tongue epinephrine
• Understanding the atopic march
• Alpha-gal (red meat) allergy
• Eosinophilic gastritis

Latest News on Food Allergies

Under-the-Tongue Epinephrine Film, Anaphylm™, Shows Positive Performance Compared to Other Forms of Epinephrine
Aquestive Therapeutics released topline data from a recent study looking at their product, Anaphylm. Anaphylm is a new form of epinephrine that goes under the tongue. The study tested Anaphylm against other forms of epinephrine. The results shows that Anaphylm worked as well as current forms to deliver epinephrine into the body. The product was also safe and well-tolerated among study participants. Anaphylm will still need to be approved by the FDA before becoming available, but these results are promising for the future of treating severe allergic reactions.

New Study Shows How Allergies Can Progress in Kids
A new study sheds more light on how allergic diseases can progress in children. In the largest study of its kind, researchers used electronic health record (her) data from more than 200,000 patients to look at patterns of allergies in children across the United States. The results validated the pattern of the “allergic march.” This is when allergies first appear as eczema, followed by food allergies, asthma, and environmental allergies. The researchers found that the average peak age of onset was approximately 4 months for eczema, 13 months for anaphylactic food allergies, 13 months for asthma, 26 months for allergic rhinitis, and 35 months for eosinophilic esophagitis (EoE). The researchers also looked at demographic trends and found that there was a much higher number of Black children with eczema and asthma, a higher number of white children with EoE, and a much lower number of Hispanic children with anaphylactic food allergies. These results are important to highlight patterns for families and doctors to improve diagnosis and treatment in childhood.

Emerging Tick Bite-Associated Meat Allergy Potentially Affects Thousands
The Centers for Disease Control and Prevention (CDC) reports that a condition called alpha-gal syndrome (AGS), also known as the red-meat allergy or tick bite meat allergy, is more common than previously thought. Alpha-gal is a sugar found in meat from mammals and products made from mammals. AGS is connected to tick bites. People with AGS can experience various symptoms like rash, digestive problems, breathing difficulties, and more usually a few hours after consuming foods with alpha-gal. Between 2010 and 2022, more than 110,000 suspected cases were identified, but it's estimated that as many as 450,000 people in the U.S. might have been affected. Two studies show that many health care providers aren't aware of AGS and may not know how to diagnose or manage it properly. It's essential for people with symptoms of AGS to see a health care provider who can properly diagnose and manage the condition.