Will an EpiPen Auto-Injector That's Been Frozen Still Function?

 

Kids With Food Allergies is sharing this press release from the 2018 ACAAI Scientific Annual Meeting to bring you the latest research news quickly.

Epinephrine auto-injectors needs to be kept at room temperatures (68-77 °F, or 20-25 °C). This study only looked at EpiPen devices and not any other brands of epinephrine auto-injectors. A previous study looked at the affects of extreme heat and cold on epinephrineThis study looked at how freezing temperatures affects the firing mechanism of the device.


[PRESS RELEASE]

Will your epinephrine auto injector still work if it gets frozen?

Probably, but still best to avoid freezing.

SEATTLE (November 16, 2018) – If you are one of the millions of people in the U.S. who has a severe allergy and carries an epinephrine auto injector (EAI) you may have wondered if it will still work if it gets left in your car in winter and freezes. Turns out it will still work, according to new research being presented at the American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting.

“Since many people who live in cold climates use an EAI, we wanted to explore the effects of freezing on how an EAI functions,” says Julie Brown, MD, abstract author. “Lead author and researcher Alex Cooper took 104 same-lot pairs of EAIs and froze one of each pair for 24 hours, while the other was kept at recommended temperatures as a control. Once the frozen devices were thawed, they and their controls were injected into meat.  The meat and devices were weighed both before and after firing.  The change in meat weight and device weight was similar between frozen-thawed devices and their controls, indicating that freezing did not affect how the EAIs functioned once they were thawed.”

Allergists recommend using epinephrine as the first line of defense in treating anaphylaxis. The consequences for not using epinephrine when it is needed are much more severe than using it when it might not be necessary.

“Many people who use EAIs have been concerned about the current shortage of EpiPens,” says allergist Anne Ellis, MD, chair of the ACAAI Anaphylaxis Committee. “It’s important for those who have severe, life threatening reactions to their allergies to have confidence in the EAIs they carry and know they’ll work in an emergency. This study showed that even when an EAI has been unintentionally frozen, the risk is low that it will malfunction.”

If you have an EAI that was unintentionally frozen, and you experience an anaphylactic reaction, it’s better to use a ‘thawed’ device than nothing at all. However, you should talk with your allergist about a prescription for a new device.

“The study did not examine the amount of epinephrine remaining in the solution after it had been frozen,” says Dr. Ellis. “We know epinephrine is a somewhat unstable compound, and that’s why the shelf life of EAIs is so short.”

If you have a severe allergy that could result in anaphylaxis, see an allergist. Allergists are trained to help you live the life you want by working with you to treat allergic diseases and avoid severe reactions.

Abstract Title: The Effects of Freezing on Epinephrine Auto-Injector Device Function
Author: Julie Brown, MD, Alex Cooper

For more information about anaphylaxis and to locate an allergist in your area, visit AllergyandAsthmaRelief.org. The ACAAI Annual Meeting is November 15-19, 2018 at the Washington State Convention Center in Seattle. For more news and research from the ACAAI Scientific Meeting, go to our newsroom – and follow the conversation on Twitter with #ACAAI18

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