Epinephrine is a lifesaving medicine for people with severe allergies. It is important to discuss with your doctor about what is the most appropriate prescription for your family. You may also need to find out which options your insurance provider prefers. This will affect your out-of-pocket costs.
Each device has its own unique set of instructions. Understanding those differences is important so that you get the device you want and you know how to use it.
Pharmacists must follow state and federal regulations when filling your prescription for epinephrine. You should keep this in mind when filling your prescription.
Current Available Epinephrine Auto-Injectors and Pre-Filled Syringes in the United States
Epinephrine injection, USP auto-injector
Epinephrine injection, USP auto-injector, made by Lineage Therapeutics, is the authorized generic of Adrenaclick®. It is available in a package of two injectors. Trainers are available upon request. Lineage Therapeutics offers a copay coupon card.
Watch the training video for Lineage's Epinephrine injection, USP auto-injector.
In addition, CVS Health is selling these generic epinephrine auto-injectors at all CVS Pharmacy locations at a cash price of $109.99 for a two-pack.
AUVI-Q®
Kaléo has discount programs for both patients with commercial insurance and patients without commercial or government insurance coverage.
Eligible patients with commercial insurance can get AUVI-Q through their AUVI-Q Direct Delivery Service. The company said U.S. residents with commercial insurance, including those with high-deductible plans, will be able to obtain AUVI-Q for $0 out-of-pocket. Order directly from Kaléo by giving the enrollment form
to your doctor.
AUVI-Q is available free of charge to U.S. residents with a household income of less than $100,000 who do not have government or commercial prescription drug coverage through their kaléo Cares Patient Assistance Program. But patients who qualify for Medicaid may be able to receive AUVI-Q for free.
Call 1-877-30-AUVI-Q for questions about eligibility.
AUVI-Q is available in three sizes: 0.1 mg (16.5 to 33 pounds), 0.15 mg (33 to 66 pounds) and 0.3 mg (over 66 pounds).
Watch the training video for Kaléo's AUVI-Q epinephrine auto-injector.
EpiPen® and EpiPen Jr®
EpiPen® and EpiPen Jr® made by Mylan, come as a two-pack with a trainer. Mylan offers a copay coupon card to reduce out-of-pocket expenses up to a maximum of $300 per EpiPen 2-Pak® prescription. The card remains valid for up to six two-packs per year. Mylan also offers a patient assistance program for patients who meet their eligibility requirements.
Watch the training video for EpiPen® and EpiPen Jr®.
Epinephrine injection, USP auto-injector
Epinephrine injection, USP auto-injector, made by Mylan, is the first authorized generic (AG) for EpiPen®. To save on this version, get the MyGenericEAI Savings Card for a savings of $25 for the generic epinephrine auto-injector.
Note: Both the Mylan and MyGenericEAI sites state the savings cards expire Dec. 31, 2018. But according to a Mylan representative, you can still download and use the savings cards. If your pharmacy does not accept the cards, your pharmacist can call Mylan to confirm at 800-657-7613 (8 am-8 pm EST, Monday-Friday).
Watch the training video for Mylan's Epinephrine injection, USP auto-injector.
Teva generic epinephrine auto-injector
Teva Pharmaceutical Industries makes a generic version of the EpiPen®. It is available in the 0.15 mg and 0.3 mg versions.
Teva offers a savings card for up to $30 off a two-pack with commercial insurance. It is good for three cartons per prescription.
Watch the training video for Teva's epinephrine auto-injector.
SYMJEPI™ pre-filled epinephrine syringe
SYMJEPI™ from Sandoz (a Novartis division) is a portable syringe pre-filled with epinephrine. It comes in a two-pack and is available in 0.15 mg and 0.3 mg. With insurance, the SYMJEPI Savings Program covers up to $300 per prescription, up to $1,000 per year. Eligible patients may pay as little as $0. People without insurance coverage receive $100 off each prescription.
Watch the training video for SYMJEPI pre-filled syringe.
Options on the Horizon
- INSYS Therapeutics received Fast Track Status from the FDA for their epinephrine nasal spray in August 2018. It is currently in development.
- Oval Medical is testing a new, compact auto-injector called EpiQ that may enter the UK market in 2019.
- Windgap Medical is also designing a compact, more temperature stable auto-injector called ANDIPen®. They have partnered with ALK-Abelló to distribute the ANDIPen and hope to submit their auto-injector for FDA approval in the near future.
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Originally published September 2016. Updated August 2019.
Comments (2)
This blog post was updated in July 2019 to include updated information on savings programs for AUVI-Q® and EpiPen®. It also includes information on the SYMJEPI™ pre-filled syringe from Sandoz.
This blog post was updated in December 2018 to include information on the generic epinephrine auto-injector from Teva Pharmaceutical Industries and the nasal spray from INSYS Therapeutics.