Epinephrine is a life-saving medicine for people with severe allergies. It is important to discuss with your doctor about what the most appropriate prescription is for your family. You may also need to find out which options your insurance provider prefers. This will affect your out-of-pocket costs.
Each device has its own unique set of instructions. Understanding those differences is important so that you get the device you want and you know how to use it.
Pharmacists must follow state and federal regulations when filling your prescription for epinephrine. You should keep this in mind when filling your prescription.
Current Available Epinephrine Auto-Injectors and Pre-Filled Syringes in the United States
Epinephrine injection, USP auto-injector
Epinephrine injection, USP auto-injector, made by Amneal Pharmaceuticals, is the authorized generic of Adrenaclick®. It is available in a package of two injectors. Trainers are available upon request. Amneal Pharmaceuticals offers a copay coupon card.
In addition, CVS Health is selling these generic epinephrine auto-injectors at all CVS Pharmacy locations at a cash price of $109.99 for a two-pack.
Kaléo has discount programs for both patients with commercial insurance and patients without commercial or government insurance coverage.
Eligible patients with commercial insurance can get AUVI-Q through their AUVI-Q Direct Delivery Service or Walgreens pharmacies. The company said U.S. residents with commercial insurance, including those with high-deductible plans, may be able to get AUVI-Q for a little as $0 out-of-pocket. Order directly from Kaléo by giving the enrollment formto your doctor.
AUVI-Q is available free of charge to U.S. residents with a household income of less than $100,000 who do not have government or commercial prescription drug coverage through their kaléo Cares Patient Assistance Program. But patients who qualify for Medicaid may be able to receive AUVI-Q for free.
Call 1-877-30-AUVI-Q for questions about eligibility.
AUVI-Q is available in three sizes: 0.1 mg (16.5 to 33 pounds), 0.15 mg (33 to 66 pounds), and 0.3 mg (over 66 pounds).
EpiPen® and EpiPen Jr®
EpiPen® and EpiPen Jr® made by Mylan, come as a two-pack with a trainer. Mylan offers a copay coupon card to reduce out-of-pocket expenses up to a maximum of $300 per EpiPen 2-Pak® prescription. The card remains valid for up to six two-packs per year. Mylan also offers a patient assistance program for patients who meet their eligibility requirements.
Watch the training video for EpiPen® and EpiPen Jr®.
Epinephrine injection, USP auto-injector
Epinephrine injection, USP auto-injector, made by Mylan, is an authorized generic (AG) for EpiPen®. To save on this version, get the MyGenericEAI Savings Card for a savings of $25 for the generic epinephrine auto-injector.
Teva generic epinephrine auto-injector
Teva Pharmaceutical Industries makes a generic version of the EpiPen®. It is available in the 0.15 mg and 0.3 mg versions.
Teva offers a savings card for up to $30 off a two-pack with commercial insurance. It is good for three cartons per prescription.
SYMJEPI™ pre-filled epinephrine syringe
SYMJEPI™ from US WorldMeds is a portable syringe pre-filled with epinephrine. It comes in a two-pack and is available in 0.15 mg and 0.3 mg. With insurance, some patients may pay as little as $0 per prescription with the SYMJEPI Savings Program.
Options on the Horizon
- INSYS Therapeutics received Fast Track Status from the FDA for their epinephrine nasal spray in August 2018. Hikma Pharmaceuticals acquired INSYS in August 2019. The nasal spray is currently in development.
- Bryn Pharma is also developing an epinephrine nasal spray. If approved, their device would contain two doses.
- Windgap Medical is also designing a compact, more temperature-stable auto-injector called ANDIPen®. They have partnered with ALK-Abelló to distribute the ANDIPen and hope to submit their auto-injector for FDA approval in the near future.
- Rx Bandz is developing the MiniJect™ that would be smaller and more temperature resistant.
- Crossject is working on ZENEO®, a needle-free epinephrine device.
- Aquestive Therapeutics has started clinical trials on its sublingual epinephrine film.
Originally published September 2016. Updated March 2021.